![]() ![]() 4 GBCAs are typically excreted by the kidneys, with an elimination half-life of approximately 90 minutes in patients with normal renal function. 2 After intravenous administration, GBCAs distribute into accessible extracellular spaces, with a distribution half-life of approximately 10 minutes. ![]() ![]() The chelation of gadolinium to organic ligands promotes bio-distribution within the extracellular interstitial space while enhancing renal filtration. While differences do exist among the gadolinium compounds in terms of various physicochemical characteristics, stability, concentration and relaxivity appear to have a major clinical impact. They can be categorised by their chemical structures into linear and macrocyclic agents and further subdivided by their charge (ionic or non-ionic). GBCAs consist of the active substance gadolinium and a chelating agent. Molecular Structure and Physicochemical Characteristics In response to the growing interest in this topic, this article will address the differences between gadolinium-based MRI contrast agents with regard to their molecular structure and physicochemical properties, providing evidence of the advantages of some compounds in terms of stability, relaxivity and concentration. Greater importance has recently been placed on GBCAs and chelate stability, particularly with the possible association between the development of nephrogenic systemic fibrosis (NSF) in patients with kidney failure. The differences between the molecular structures of the gadolinium chelates affect their physicochemical characteristics. These contrast agents have been used extensively in a large range of indications, particularly central nervous system examinations, as well as neurodegenerative diseases and tumoural disease processes, among others.Ĭontrast enhancement has enabled improved tissue contrast and lesion characterisation and more sensitive detection of even very small lesions. Since the original conception and introduction of magnetic resonance imaging (MRI) gadolinium-based contrast agents (GBCAs) in the 1980s, many such contrast agents have been approved for use in contrast-enhanced MRI. ![]() Gadolinium-based contrast agent (GBCA), contrast-enhanced magnetic resonance imaging, stability, relaxivity, concentration Article: With high stability, relaxivity and concentration, gadobutrol has been shown in a number of clinical studies to be safe while improving image enhancement with increased conspicuity and sensitivity over other commonly used GBCAs. Among these compounds, only gadobutrol is commercially available at a higher concentration of 1.0M, whereas the others are used at a standard concentration of 0.5M. Gadobutrol, gadobenate and gadoxetic acid have relatively high relaxivities. Relaxivity and concentration are contributing factors to the level of enhancement that can be achieved with any given GBCA. GBCAs can be categorised into three stability classes: non-ionic linear agents, ionic linear agents and macrocyclic agents, in order of increasing stability. The stability, concentration and relaxivity of a GBCA can have a major impact on clinical efficacy. Gadolinium-based contrast agents (GBCAs) are commonly used to enhance image acquisition via magnetic resonance imaging, but they differ in their physicochemical characteristics and therefore their function. ![]()
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![]() Code without friction.How do I run ejabberd tests in the test folder? On-the-fly recompiling and reloading in Erlang. Riak is a decentralized datastore from Basho Technologies. Sarama is a Go library for Apache Kafka 0.8 and 0.9Ī linked-in driver for Erlang to Mozilla's Spidermonkey Javascript runtime.Įrlang build tool that makes it easy to compile and test Erlang applications, port drivers and releases. Small, fast, modular HTTP server written in Erlang. Generic plugin & hook system for Erlang applications Never lose your childlike sense of wonder baby cuttlefish, promise me? Papers from the computer science community to read and discuss.Įrlang build tool that makes it easy to compile and test Erlang applications and releases. :books: Freely available programming books Lasp driven process group registry for Erlang.įlexible, fast and powerful supervisor library for Erlang processes MongooseIM is a mobile messaging platform with focus on performance and scalability This is advanced Erlang socket library for TCP protocols and provides fast, useful and easy-to-use API for implementing servers, clients and connection pools. Tsung is a high-performance benchmark framework for various protocols including HTTP, XMPP, LDAP, etc. Open source multi-protocol messaging broker ![]() High-Performance Erlang Network Client FrameworkĪn XMPP client library in Erlang for conveniently testing XMPP servers Thrift Erlang Software Library, subdirectory of official repo()īasic measurement objects and probe behavior Ebot is written in Erlang and it is a very scalable, distribuited and highly configurable web cawler. Redis simulator using erlang process dictionary for key/value storeĪ Thrift client wrapper that encapsulates some common failover behaviorĮbot, an Opensource Web Crawler built on top of a nosql database (apache couchdb, riak), AMQP database (rabbitmq), webmachine and mochiweb. TiDB is a distributed NewSQL database compatible with MySQL protocol Kakaranet SNMP Monitoring Erlang Application ![]() Monitoring and REST interface to rabbitmq Simple OTP app for managing Erlang VM system_monitor event messagesĪ curated list of awesome Erlang libraries, resources and shiny things.Ĭollection of top articles reflecting the Zen of Elixirĭockerfile for Redis Cluster (redis 3.0+)Ī top-like tool for monitoring an Erlang node 算法实践(JavaScript & Java),排序,查找、树、两指针、动态规划等Ī Streaming Process-based Skeleton Library for Erlang Tool to convert Erlang cover data files into Cobertura XML reportsĪlgorithms and data structures implemented in JavaScript with explanations and links to further readings High-Performance MQTT Server and MQTT cluster ![]() High-Performance MQTT Server and Client Libraries 机器(点)间间互PING检测工具,支持互PING,单向PING,绘制拓扑及报警功能。ĭistributed reliable key-value store for the most critical data of a distributed system :book: 作为对《C++ Concurrency in Action》英文版的中文翻译。Ī distributed MQTT message broker based on Erlang/OTP The proper way to submit changes to nginx is via the nginx development mailing list, see Ī custom formatter for the Erlang logger application that turns maps into single line text logsĮmacs setup for C/C++ with Helm describe here: Pull requests on GitHub cannot be accepted and will be automatically closed. 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Hot Shot’s Secret announces the immediate rebranding of Transmission Stiction Eliminator to Shift Restore. ![]() ![]() SKU 10574160-Hot Shot's stiction eliminator for gas and diesel engines safely removes and prevents the gummy, sticky residue that builds up inside diesel HEUI injectors over time. ![]() ![]() ![]() Construction Simulator Extended Edition Steam key also lets you be the God figure of the game and control all the surroundings. The peculiar nature of real life experiences with intriguing features makes one capable of anything. In the vehicle hall there is a button in the middle of the screen to instant repair your vehicles. There’s quite something about Simulator games that always brings you back to it. Select a vehicle you want to repair and choose show in vehicle hall from the options menu. We have provided direct link full setup of the game. In the company menu check the vehicle fleet menu.
![]() This processor stands with a Base …The Radeon version built into the Ryzen 5 4500U chip has six graphics processing cores. AMD RyProcessor AMD RyProcessor is 6 processor cores, 12 threads, and an astonishingly efficient 45-65W TDP. Advanced: Daily Deals Brand Outlet Help & Contact. Find many great new & used options and get the best deals for HP ProBook 445 G7 AMD Ryzen 5 4500U 12GB Ram 256GB SSD at the best online prices at eBay! Free shipping for many products! Skip to main content. The integrated Vega graphics are decent for playing games at 900p medium for the most part.Ryzen 5 4500: 6/12: 4.1/3.6: $129: Ryzen 3 4100: 4/8: 4/3.8: $99: There's one more chip AMD has announced more details on today, the Ryzen 7 5800X3D (opens in new tab). Very good Ryzen APU! Perfectly equipped to take on most everyday tasks and even many heavy ones, this CPU will be great for basically anybody on a mobile laptop chip. Cinema 4 is a worldwide …AMD Ryzen 5 4500U Description: with Radeon Graphics Class: Laptop Socket: FP6 Clockspeed: 2.3 GHz Turbo Speed: 4.0 GHz Cores: 6 Threads: 6 Typical TDP: 15 W …Ryzen 5 4500: 6/12: 4.1/3.6: $129: Ryzen 3 4100: 4/8: 4/3.8: $99: There's one more chip AMD has announced more details on today, the Ryzen 7 5800X3D (opens in new tab). Shipping: パソコン工房 PayPayモール店 | iiyama PC デスクトップPC SOLUTION-M0P5-R45-NBX-M カテゴリー スマホ、タブレット、パソコン,デスクトップパソコン,Windowsデスクトップ 平置きサイズ/ Ryvs Intel Core i3-12100 Benchmark, comparison and differences AMD Ryvs Intel Core i3-12100 Last updated: CPU comparison with benchmarks Cinebench R23 (Single-Core) Cinebench R23 is the successor of Cinebench R20 and is also based on the Cinema 4 Suite. AMD RyGaming PC 16GB RAM Nvidia 12GB RTX 3060 480GB SSD Windows 11 Condition: New Operating System Quantity: 5 available Price: GBP 759.99 ApproximatelyUS $946.19 Buy It Now Add to cart Add to Watchlist Breathe easy. 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The AMD Ryaveraged 24.6% lower than the peak scores attained by the group leaders. AMD Rywith Wraith Stealth Cooler : Item model number AMD Ry: Item Weight 2.79 ounces : Product Dimensions 1.57 x 1.57 x 0.24 inches : Item Dimensions LxWxH 1.57 x 1.57 x 0.24 inches : Color Ceramic Gray : Processor Brand AMD : Number of Processors 6 : Batteries 1 Unknown batteries required. This shows the performance advantage associated with AMD's Zen 3 architecture over the older Zen 2, as well as the benefit of significantly larger cache. The Ryperformed exceptionally well in Cinebench R23, coming in just slightly behind the pricier Ryzen 5 5500, but in every other test it trailed the Rysignificantly.RyAMD Ryzen™ 5 5500 6-Core, 12-Thread Unlocked Desktop Processor with Wraith Stealth Cooler Visit the AMD Store 1,494 ratings | 59 answered questions -39% $9698 List Price: $159.00 FREE Returns See more About this item Can deliver fast 100 plus FPS performance in the world's most popular games, discrete graphics card requiredEWE računar PC AMD Ryzen 5 4500/8GB/500GB/GTX1650 4GB/600W: Procesor: AMD® Ryzen™ 5 Hexa-Core 4500, 3,6 GHz do GHz (T, cache) Matična ploča: ploče GA B450M K: Procesorsko ležište (socket): AMD AM4: Čipset: AMD B450: Grafika: nVidia® GeForce® GTX 1650 4GB GDDR5, GV-N1650D5-4GD: RAM Memorija: 8 GB DDR4 3.200 MHz, … ![]() ![]() ![]() a string from file, inside the file > 20 5 19 20 9 14 7 python a1z26. The initial value of this semaphore will be 2 and as such we will see 2 of our worker functions successfully acquire the semaphore before then releasing it and allowing our third worker to then acquire it. This Phonetic Alphabet Translator will phoneticise any text that you enter in. ![]() ![]() 04 ''' 05 06 def init (self, urls, output): 07 ''' 08 Constructor. In this example we will create a simple instance of a semaphore and then create 3 worker functions that will try to acquire said semaphore. Contains various map-reduce example written in java and python Topics. 01 class FetchUrls (threading.Thread): 02 ''' 03 Thread checking URLs. Word Count: Count the occurrence of all the words in an input text file. Python Dictionaries Access Items Change Items Add Items Remove Items Loop Dictionaries Copy Dictionaries Nested Dictionaries Dictionary Methods Dictionary Exercise Python If.Else Python While Loops Python For Loops Python Functions Python Lambda Python Arrays Python Classes/Objects Python Inheritance Python Iterators Python Polymorphism Python Scope Python Modules Python Dates Python Math Python JSON Python RegEx Python PIP Python Try. The class FetchUrls is thread based and takes a list of URLs to fetch and a file object to write the content to. ![]() ![]() ![]() That being said, there are still a number of clicky switches that are quite good. In my opinion, this could be the reason why clicky switches are not quite as popular as its linear or tactile counterpart in the scene. Truth be told, I was a fan of clicky switches in the past, but once I’ve built a number of custom keyboards, I prefer using non-clicky switches to not mask the unique sound profile of each keyboard. Unfortunately – or fortunately, depending on who you’re asking – there aren’t as many selections of clicky switches in the custom mechanical keyboard scene. Of course, this also means it is the noisiest switch type of the lot. Not only does a clicky switch have a tactile bump, it also offers an audible click when it is actuated. If you want something with an even more pronounced feedback than a tactile switch, consider clicky switches. Alternatively, you can also consider the Glorious Panda – it emulates the very popular Holy Panda tactile switch quite well. But I find myself missing the smooth typing experience of a linear switch after some time, so make of that what you will!Īnyway, if you want to get a tactile switch, the Gazzew Boba U4T Thocky is an excellent choice it’s easily one of our favourite tactile switches in the market now that’s also (somewhat) readily available. I like to type fast, but because I need to exert more force to “overcome” the tactile bump of a tactile switch, I find myself typing quite a bit slower.ĭon’t get me wrong, I do type more accurately with tactile switches. However, for what it’s worth, I prefer linear switches over tactile. Tactile switches have a noticeable tactile bump to let you know that you have actuated them, which can help you to…well, type more accurately. If you’re a more “intentional” typist who values accuracy, you may be interested in this switch. Just like linear switches, you are spoiled for choice when it comes to tactile switches. Some of the best linear switches I have personally tried include the Gateron Ink Black, NovelKeys Cream – though you do have it break it in and lube it to bring out the switch’s best potential – and the Cobalt POM. If a linear switch sounds like the one for you, you’ll be happy to know that there are a ton of options. It also lets me type quite a bit faster than other types of switches – more on that later. The best linear switch offers very, very smooth downstroke, which offers a pleasant typing experience free of scratch, tactile bump, or audible click. As its name suggests, a linear switch provides no feedback at all throughout the downstroke until you bottom out, lending to a “linear” feeling.Īnd that is the very reason why a linear switch is my personal favourite. This is arguably the most popular switch option in the custom mechanical keyboard scene. ![]() ![]() ![]() Pope Pius XII instituted the feast of the Queenship of Mary in 1954. “You have to commit to doing what it takes.” In Ballard’s case, now, “the fruits are there for all to see.” Angels are depicted playing an ancient form of violin and a harp at Mary’s coronation in heaven. “One of the greatest challenges of the process” is keeping heart while working on a complex, time-consuming piece, said Turner. He commended Ballard for the innovative way she solved some visual challenges some “gems” in the crowns of the angels are a depression in the gold with a carefully-placed drop of ink inside. “Particularly the gold work is very masterful.” “You can see the care and attention that went into the creation of this piece. ![]() He dropped in to see the Coronation and offer a second set of eyes countless times in the three years she was steadfastly working on it. Iconographer Frank Turner has a studio down the hallway from Ballard’s. It doesn’t happen all the time, but this is what you strive for and what musicians strive for.” It’s a two-way street: God can come down to you through it. “It’s a vehicle, sacred art, through which you can travel into this world and God can also. It will remain, you just have to look at it ,” she said. You don’t know how it’s done but when you get there, you know you’re there. You listen to it and then you are taken off into this other world. She would pray and listen to sacred music or work in silence on the Coronation of the Virgin, and hopes viewers also have a meaningful, spiritual experience when they encounter it. Patricia Ballard working on the icon in her studio in 2017. “You have to be very disciplined,” said Ballard, a trained artist who produced secular works until she became a sacred artist in 1999. ![]() Perhaps the most complex part was Our Lady’s veil, which covers a large part of the icon and had to be done perfectly on the first attempt, otherwise Ballard might have had to recreate large sections of Mary’s face. Every paint colour was mixed with precision. Particularly challenging sections were the precise lines and folds of fabric, the complex tapestry in the background, and the patterns on Mary’s crown, created by adding many layers of material, then scraping away sections of gold leaf to reveal the paint beneath. “This is the most complex piece I’ve ever done, and the most challenging,” said Ballard. It took her three years and two months to complete the project using traditional tools like egg tempera paint, rabbit skin glue, and gold leaf. Michael Miller, CSB, has called it a masterpiece, while Ballard calls it a spiritual journey. Her icon differs slightly from the original, the most notable difference at first glance being its size (it is much larger at 33.5 inches by 55 inches), Jesus’ cloak changed from black to a deep blue, and the Swarovski crystals shining brightly in Mary’s crown.Īrchbishop J. These images of Mary “became common as part of a general increase in devotion to Mary in the early Gothic period and continues today,” she said. Mary’s coronation was a c ommon subject for Ital ian artists in the 13 th to 15 th centuries, said Ballard. Watching are seven archangels and four angels playing period musical instruments. The icon is a larger version of an original work by 14 th- century Italian artist Giacomo di Mino and depicts Jesus placing a crown on the head of Mary, his mother. Her latest piece, the Coronation of the Virgin, was installed in the Archdiocese of Vancouver’s Chapel of the Annunciation just before the feast of the Queenship of Mary Aug. It’s through the material that you are carried to this other world.” “You’re working through paint and wood and gold. ![]() Each person in his or her own way experiences something through it,” she said. “This is the goal: to carry the individual into the realm of the divine for the purposes of understanding, knowing, being close to God. She hopes those viewing her art also get the sense there’s more to life than the physical. “ I don’t have internet here, usually I don’t have my cellphone on, and I’m just in this space and this world where I’m wanting to communicate with God, and I want God to help me or the angels and the saints to help me work the piece.” With the music of 11 th- century nun and composer Hildegard von Bingen playing in the background, Ballard diligently pores over her work in a small studio in Port Moody, B.C., a sacred artist on a mission to connect herself and others with the divine. “I would ask God, and ask the angels,” she said. When iconographer Patricia Ballard is stuck on a challenging pattern or discouraged by a mistaken stroke of the brush, she looks to heaven for help. ![]() ![]() ![]() The sincerity of visuals is really important to me and most creators do it wrong. What inspired the world of Bomb Rush? What are some elements you feel were important influences? Then going back home to normal, which made the city seem even more like a fantasy land. Going to the city, to a jam, seeing people do this crazy stuff, competing, cheering on my friends, and just having crazy interactions skating. My city fantasyland where the hero’s journey takes place. That’s his passion and something that stays with him all his life.įor me, I came to see that going out on the street was my adventure. Then you’re collecting bugs and other stuff concerning the fact that he was outdoors a lot. Miyamoto says he used to always explore caves and in Zelda, you see nothing but those and dungeons. Sometimes I compare it to other director’s work where you can see their youth in the stuff they create. I’m not sure I can go further than this though. Now Bomb Rush seems to be the height of it. Over time, came Lethal League where I would acknowledge that I’m not the best artist but I have something nobody else has and incorporated my style choices. Just mixing some Smash Brothers with a Medabots thing. At first, the games we made were, “game games,” like our first game, Megabyte Punch. Over the years, the games have started to shape more and more into what I feel like is my honest expression. How has your style of game development evolved into the style seen in games like Lethal League and Bomb Rush Cyberfunk? We gathered more and more people we could afford over time with the money made from releasing our games, financing game after game with money made the previous one. I still apply that mentality to games, especially with Bomb Rush if you notice the similarities to another game.Īfter I graduated high school I went into games education I met my colleague and business partner and Team Reptile started as a two-man thing. I think that was a mentality I got from my hip-hop side where sampling is the way to go. There was this little car game where you’d be a driver having to dodge other cars and I changed the player car into Gohan from Dragon Ball, added the theme music, and the ability to shoot blasts. In the case of Sonic the Hedgehog, I would draw my own levels and get my little brother to play them by moving his finger across the level while I “dungeon mastered” him through the stage.Įventually, I just looked up, “make game” on Google and found the program, “Game Maker.” I’d be doing that at home anytime I wasn’t out dancing in the city and really got into taking other people’s creations and adding or changing things. While playing, I’d think things like, “I wanna make my own game!” Or I’d play a game and disagree with something and wanted to make something slightly different. The city was so full of life but at home, that was just not the case so like any kid I played video games. The other half I’d go out to Amsterdam to go to a jam, training, and other fun stuff. Half the time I’d be in my little hometown sleeping or doing my own thing in my room. What led you from that to the world of video game development? I feel like I have to honestly represent. So after being in so many places and meeting and so many influential people I don’t feel like I’m coming in with an outsider’s point of view. ![]() I got a lot of cultural things from that and met people who were growing up in Amsterdam and Almere which had a lot more going on in terms of hip-hop than our little town. We went to weekly classes taught by legendary dancers, rappers, and people in the neighborhood. We just really felt like we were a part of it and that stuck with me.įrom there, I and a few of the other more dedicated students would follow my teacher to a sort of school of hip-hop theater he taught at in Amsterdam. We really dug into the culture thanks to our teacher constantly talking about it and the history behind the art. A few others and I just started meeting at random spots and at different people’s places to jam. My mother told me about a breakdance class, I joined, and immediately fell in love. In the case of dancing, I’ve loved it since I was a kid. Dion Koster: I first started with inline skating and it quickly became a way for me and my friends to be ourselves against the average environment or something along those lines. ![]() ![]() ![]() ![]() Create a task in the time sheet app when I start an Onkho job.When I think of time sheet integrations, I think of the following scenarios: That gives us a major footprint in Zapier to accept integrations for quotes/proposals, contacts and general notifications. Practice Ignition integration comes out in a matter of days. That way you disable them in Onkho and you're done!ĭoes this all make sense? Comments, feedback, questions all welcome! Instead of remembering that you need to remove ex-team members from every single app you use, they will access all apps via Onkho. We'll also make sure that you can click on a notification and go directly to the app in question. This solves the evolving problem that we see with statuses being across multiple apps and you having to go to each one to find out what's going on. All apps will be able to send messages to your Inbox directly - no more looking for notifications across the whole of your ecosystem! It will put Onkho and Inbox where it adds the most value to you - at the very heart of your app ecosystem.Not only will it allow other apps to do a "logo integration" with us, it will also allow 2 very new and novel integrations: We can even do something cool internally like "when I complete this step, the user needs to fill out this data" and we could route that to Inbox for action! Logo integrations will also be where we see apps that aren't available on hosted solutions, like GoProposal, VirtualCabinet etc.įinally, the icing on the cake will be our API. That way you can literally integrate the integration (!!!) into your workflow! An example would be something like "when I click this step, send this Typeform to the client" or "when I complete this step, send this data to GoProposal" etc. With logo integrations, we are thinking of going well beyond the norm! We think these should include things like branded widgets, insights and steps. ![]() To be clear though, our ability to publish depends on you! We need a critical mass of users to test the integrations before Zapier will allow us to publish them. We hope to have all our triggers and actions ready and published to Zapier by the end of Jan 2020. Targeting Zapier gives us the widest range of integrations on day one including Xero, Quickbooks, Toggl and Practice Ignition. We plan to target Hosted integrations first, starting with Zapier. Logo - this is where we do custom integrations with specific apps.Hosted - this is where we allow other apps to exchange data with us by using a platform that is owned by someone else e.g.API - this is where we allow other apps to exchange data with us by using a platform that we own.We see that there are 3 types of integrations: This means other apps can do these things on your data in onkho: We're planning to support the following actions. This means that other apps will know when these things happen and take some action on their own data. We're planning to support the following triggers. This time, we want to outline how we are going to deliver integrations.Īn integration is basically "when this happens (a trigger) in app 1, then do this (an action) on app 2". Previously, we've discussed our approach - see the connected topic. So, we are finally ready to look at integrations. ![]() |
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